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01 Jul

Androstenedione is a steroid-like compound which goes about as a precursor for the amalgamation of testosterone and estrogen. It is generally accepted that androstenedione has anabolic properties. Androstenedione happens normally in the body yet can likewise be made artificially. The drug can be taken by mouth, infusion or a nasal splash.

Since androstenedione is known to transform into testosterone, there has been a considerable measure of media buildup about its potential as an anabolic steroid.

 

Beginning in the 60s, andostenedione was fabricated and has been sold as a dietary supplement. Frequently called Andro, it was generally accessible in most wellbeing and nourishment stores. Andro got overall consideration after the Mark McGwire baseball outrage. In the most recent couple of years, Andro has kept on making news, particularly in the field of expert baseball and cycling.

On the internet, both merchants and producers of androstenedione state that the medication can quickly expand muscle size and strength. These anabolic impacts help to fabricate a body which can endure extremes of activity and help recuperation of the body after damage. Others guarantee that Androstenedione can aid sexual performance, make one look youthful and even develop hair. There is not one particle of exploratory evidence to go down any of these cases. There are no thorough controlled trials that have been done to record the way that androstenedione has any anabolic properties or whatever other advantages. All the information on androstenedione have been exaggerated by deceitful producers and wholesalers of the item.

Body Building
Androstendione is a naturally occuring steroid in the body that is manufactured by a number of organs including the adrenals, ovary and testes. The androstenedione is then released into the blood and rapidly converted into the male sex hormone, testosterone. Some androstenedione is also converted into the female sex hormone, esterogen, in the peripheral (fatty) tissues. In all individuals, the manufacture of androstenedione in the adrenal gland is controlled by the pituitary hormne ACTH, whereas the production of gonadal androstenedione is under the control of gonadotrophins, LH and FSH.

There are several reasons why individuals take androstenedione.

The one major reason why anabolic steroids have become popular is that there is a wide spread belief that this agent can help increase body and muscle mass. For decades, sports athletes, both professionals and amateurs have been trying to get a quick fix to their body size. Everyone wants to throw further, run faster, lift more and play better. While the exact number of athletes who take anabolic steroids is not known, the numbers are indeed high. The problem is not only in professional sports but also at college and high school level. The lure of money in professional sports has everybody pumping steroids. Surveys from schools indicate that at least 3-9% of all high school athletes have tried out some type of performance enhancing drug. And this includes both genders. The problem is not only seen in North America but appears to be common in Europe, Russia, and even some parts of Africa.

The first reason is reason why androstenedione is the hormone of choice by body builders and athletes is because testosterone is not effective when taken orally. Testosterone is rapidly broken down by the liver before it can interact with the tissues. To circumvent this problem of rapid metabolism of testosterone, many formulations of androstenedione have been developed.

Detection
Another reason why androstenedione is preferred by athletes is that when taken orally, the levels of the drug decline very rapidly, making it undetectable within a few hours or even days. Because androstenedione levels can not be measured, the levels of testosterone are measured instead. The ratio of testosterone and epitestosterone is normally between 2-3:1. Androstenedione can alter this ratio to about 10:1 or higher. According to the Olympic Committee, when this raio is greater than 6:1, it is consdered positive for abuse of anabolic steroids. Most athletes take androstenedione for a few months and then stop it a few weeks before the sporting event. This will gradually diminish the levels of testosterone and hence avoid detection.

Dosing
Androstenedione Injection Androstendione is available in various formulations. It can be taken as a pill, injection or a spray. The spray is usually placed underneath the tongue and results in very rapid absorption of the drug. The dose of androstenedione is variable, some body builders take 100mg/day and others take 300 mg/day. The drug is taken for a few months. When androstenedione is taken as a pill, the majority of it goes to the liver where it is immediately broken down into inactive metabolites.
There are also other formulations of androstenedione which come as pastes or gels. These gels are simply rubbed or applied on the skin and are slowly absorbed into the body. Their effectiveness is questionable because the levels found in the body are very low. For Androstenedione to work as a anabolic steroid, it must be converted into testosterone.
Androstenedione Benefits?
When Androstenedione is taken by an individual, it can increase the levels of serum testosterone within a few hours. The dose at which androstenedione increases testosterone levels is around 300 mg/day. Any dose lower than 200 mg/day does not increase levels of testosterone. However, there is no correlation between the dose of androstenedione and the levels of testosterone. Some individuals do show increase in testosterone and others do not- this is believed to be due to the rapid breakdown of testosterone. Bodybuilding Androstenedione Athlete
Many studies have looked at the effects of androstenedione on muscle mass and strength. At the lower doses (less than 100 mg/day), androstenedione has no effects on any organs in the body. At 300 mg per day, the data is controversial because all the studies so far have been carried out in a non randomized fashion. Some studies do reveal an increase in muscle mass, and some show no effects. However, at higher then 300-500 mg/day, there are anecdotal reports that the drug does increase body mass. However, even these studies are conflicting because many individuals were also taking other supplements to promote muscle growth.
Potential Long-Terms Risks

Androstenedione as such has no side effects. The side effects occur from the conversion to the male sex hormone, testosterone and the female sex hormone, estrogen. The commonly reported side effects in individuals who take high doses of Androstenedione include:

Males

  • breast enlargement
  • growth of prostate
  • risk of prostate cancer
  • impotence, loss of sex drive
  • acne
  • oily skin
  • loss of hair

Females

  • growth of facial hair
  • deep voice
  • enlargement of genitals
  • risk of blood clots in the legs
  • risk of endometrial cancer
  • masculine features

Legal Implications
Since the beginning of 2001, the Federal Government and many sports agencies have become concerned regarding the use of anabolic steroids among athletes. In March of 2004, the US senate introduced the Anabolic Steroid Control Act adding these drugs on to the controlled substances list. What this means is that anyone caught with these products without a legal prescription from a physician are committing a Federal crime. Later in April of 2004. Androstendione was taken off the market and is no longer available for sale. Today, the FDA and DEA closely monitor the sell of this drug, esp on the internet. The penalities for those caught in possession or distribution of this drug are harsh and include both monetary fines and jail time. Penalty for Possession of Androstenedione

Cost
The product is widely sold over the internet. For a 30 day supply of 100 mg pills, cost is anywhere form $15-50. However, one should be aware that there are many conterfeit products in cyberspace. Analysis of products bought over the internet have shown that many products claiming to be androstenedione are infact fake and only contain a variety of harmless sugars.

Conclusion
The current recommendations are that androstenedione has minimal or no effects on the body and should not be taken to promote body growth. Plus, the long term side effects remain unknown. One other feature of this drug that all males should know is that androstenedione is also converted to the female sex hormone, estrogen- so unless a male is undergoing a sex change procedure, androstenedione should be avoided.

Today, the role of Androstenedione as an anabolic steroid is in question. Most of the manufacturers or sellers (esp. on the internet) claim that it can increase body mass and size. These claims are also made by many sports athletes. However, none of these claims are scientifically proven. In the end, one can decide what one wants- a smooth skin with a healthy body or lots of acne, oily skin, risk of cancer and loss of sex drive- the choice is very simple.

22 Jun

Utimate Fighting Championship (UFC) middleweight contender, Sam Alvey, may not be winning any popularity contests this year from his associates, due to his recent revelation that 90-percent of the program is taking steroids.

The remarks – which he made on the P4P Podcast (through Bloody Elbow) – were incited when talking about Fedor Emelianenko’s magnificent run under the now-old PRIDE FC mixed martial arts (MMA) promotion – was likely supported with the assistance of performance enhancing drugs (PEDs).

While Alvey didn’t outright blame the best heavyweight fighter of roiding, he did say that if that was the situation, then all he was doing was leveling out the playing field, as PRIDE didn’t tests for PEDs.

 

“Everyone takes them. I think even in today’s UFC most the guys today take them. It was an even playing field even if he (Fedor) was on steroids so was everyone else.”

When asked to give his estimate as to how many fighters on the UFC roster he felt were taking steroids (him excluded, of course) Alvey’s number was alarmingly high.

“I’m saying 90% … Yeah, human beings don’t look like this.”

Of course, unlike PRIDE, UFC is zero tolerance when it comes to PED’s. And after the new-and-improved testing goes into effect on July 1, 2015, Alvey’s astronomically-high percentage will go down.

Which means plenty of fighters that once dominated their respective opponents, will look like a shell of their former selves. This should make for a reality TV show on steroids (pun intended)

But, Alvey says, like in baseball, people will still find a way to cheat:

“Yeah, I do (think people will get busted.)In baseball they make a lot more money so they can pay for the really good drugs. People will always find a way to cheat, it’s just the way they are and they will just pay to get the drug they are not testing for. What’s that red deer antler thing everyone uses in baseball right now? Now they are testing it for it everyone will find some … frog so they get super strong, something they aren’t testing for yet. People always find a way to cheat. You can’t always tell but you can usually tell.”

Time will tell.

When the new testing for illegal anabolic steroids and other PED’s go into effect, that will truly separate the boys from the men.

06 Jun

Anadrol Oxymetholone 

Anadrol (oxymetholone) is a synthetic steroidal drug available as a tablet. it is a potent oral anabolic and androgenic drug.
Anadrol is an anabolic steroid. It enhances nitrogen offset when the eating regimen is adequate in calories. The activities of anadrol are like testosterone and can bring about genuine impedance in sexual and physical development when given to kids. Kids who have taken this medication create bizarre physical components and as a rule have scattered sexual capacity.

 

PHARMACOLOGY
Biochemical Analysis of Anadrol Anadrol, is sold under the pharmaceutical name Oxymetholone, and has a half existence of around 8-10 hours. This implies it stays in your body for 2-4 times longer. The reason it stays in the body longer is a direct result of its natural inclination for greasy tissues where it gets put away.

Biochemical investigation have demonstrated that Anadrol can be distinguished in the body for up to 2 months after the last measurements. As a result of this long half life, it is not the favored medication of decision by numerous jocks. Most specialists suggest it as an off season medication to construct the body.

Indications
In clinical prescription, Anadrol has been shown in the treatment of anemias from an assortment of distinctive reasons. The most widely recognized frailty treated with Anadrol is iron inadequacy pallor, gained aplastic sickliness, intrinsic aplastic paleness, myleofibrosis and the weakness created by the utilization of immunosuppressive medications. Anadrol is not a swap for iron, blood transfusion, vitamin, folic corrosive or different supplements. It is just used to treat these anemias after they have neglected to react to all other strong measures.

The medication has likewise been suggested for the treatment of squandering seen in HIV patients and in people with extreme osteoporosis. On the other hand, on account of the more noteworthy consciousness of its potential symptoms, most doctors don’t recommend it.

Dose
The dose of Anadrol is based on body weight. In both adults and children this is about 1.5mg/kg. When Anadrol is administered to treat any of the above medical disorders, its response is never immediate and may take a minimum of 2-3 weeks. In some patients a slightly lower dose is required to maintain its benefit when treating aplastic anemias. Anadrol is only available as a tablet and never given intravenously.

Side effects
Before one use Anadrol there are a few things you should know. Anadrol is a potent steroid and is associated with a fair number of side effects which include:

  • Liver Side Effects of Anadrol
  • jaundice
  • possibility of liver cancer
  • enlargement of penis if taken before puberty
  • testicular atrophy and low sperm count if taken after puberty
  • impotence, painful penile erections
  • in women- clitoral enlargement, menstrual irregularities
  • lack of sleep
  • gynecomastia- breast enlargement
  • deepening of voice
  • excessive hair growth
  • general fatigue
  • swelling of the body
  • high sugars

Contraindications

  • cancer of the prostate
  • male breast cancer
  • female breast cancer
  • pregnant females
  • those with liver problems
  • those who have allergies to the drug

 

Body building
Anadrol is a generally utilized medication among competitors and weight lifters. It an effective anabolic steroid and moderately economical. The medication is anything but difficult to get hold off on the bootleg market. The greater part of the meat heads get their supplies either online or from manufactured medicines. The steroid is likewise broadly snuck in from Mexico and Thailand.

Bodybuilding Athlete
At the point when Anadrol is taken orally, it steadily begins to build weight pick up. The outcomes are commonly seen following 3-4 weeks. While there are claims in the internet that weight increase can happen in 1-2 weeks, these are totally false. The medication demonstrations gradually. To keep up the weight increase most competitors need to take it for no less than 3-6 weeks. Numerous competitors likewise reuse the medication with development hormone and thyroxin. One noteworthy symptom of Anadrol is that it additionally causes water maintenance. Then again, most competitors claim that this abundance water helps pad the joints against damage.

The other component about Anadrol which has been generally reported is that it does help the body recoup much speedier after a harm.

In view of it strong reactions and the potential for creating malignancy in the liver, its use ought to be restricted. Numerous muscle heads reuse the medication at regular intervals to keep up the mass. The Anadrol is substituted with other anabolic steroids.

Late reports show that Anadrol can likewise have capricious consequences for the mind. The medication has been known not the mind after drawn out utilization. Numerous reports of unconstrained annoyance, peevishness and roughness have been accounted for in people who take this medication for delayed periods.

The measurements for weight lifting is exact. Most specialists in iron pumping suggest beginning off at 50 mg every day for 2-3 weeks and after that progressively expanding it to 75 mg if no reaction is seen. Then again, it is exceptionally prescribed that the medication not be taken for more than 6-8 weeks on end. There are different brand names of Anadrol available, for example, Thai 50 or Strol V. Reports of fake and defiled items are additionally normal.

Cost
Anadrol is a relatively pricey drug. 100 tablets cost anywhere form $150-$200

Control
The widespread abuse of Anadrol has led to greater control and restriction of its use and distribution in North America. Anadrol is a controlled substance listed as a Schedule 111 drug under the Controlled Substance Act. It requires a physician’s prescription. Anyone caught with the drug for the purpose of selling or distributing it can face significant monetary fines and even jail time.

Detection
The drug is now banned by all sporting organizations and is regularly tested for in athletes. Positive tests usually mean suspension of the athlete. Anadrol and its metabolites can be easily identified in the urine for 20-45 days after the last dose.

06 Jun

Testosterone Cypionate is long acting formulation of testosterone which is indicated in the treatment of individuals who have absent or very low levels of the hormone. It is sometimes known as Depo testosterone. The testosterone is esterified and thus is quite long acting. It is only available in an injection form. The anabolic steroid is typically dissolved in sesame or cotton seed oil and injected into the buttock area. The drug is slowly released from the injection site for about 7-12 days.

The formulation comes as white milky powder and is insoluble in water but freely soluble in most organic solvents including vegetable oil.

Pharmacology

The body normally makes sex hormones like testosterone which is responsible for the normal growth and development of the secondary sexual features. This includes growth of the prostate, testes, penis, scrotum, body hair, vocal cord thickening, alterations in body fat and musculature. When testosterone deficiency occurs, the secondary sexual characteristics and body growth is always abnormal. Thus, one of the indications of testosterone therapy is in the treatment of individuals who lack testosterone or are infertile.

Indications for use

Testosterone Cypionate is used to treat conditions in made where there is a failure of testosterone to be secreted like:

  • primary failure of the testes to make the hormone
  • failure of the pituitary to release Gonadotropins

Bodybuilding

Testosterone and its analogues are widely used by athletes and bodybuilders. The steroid is taken principally to enhance the body and stimulate the psyche. Most bodybuilders who take this drug claim that it causes spontaneous bursts in energy associated with increased aggression. This feature of the drug is used primarily by weight lifters and professional wrestlers. Many athletes also claim that the drug improves their ability to perform exercise at intense levels.

Testosterone has moderate anabolic properties but also is a powerful androgenic agent.

Because the drug is given by an injection, its effects on the body are not rapid. One may not see any effects for at least 3-4 weeks after starting the injections. Unlike the oral testosterone, the injected formulations last a longer in the body.

When taken for more than 4-6 weeks, it can increase body mass and protein anabolism. However, for the body to build muscle one also has to eat a diet rich in calories. Most bodybuilders also take a combination of other hormones at the same time. Because testosterone is converted to estrogen in the fatty tissues, there is always the chance of developing gynecomastia and water retention. To prevent this, most bodybuilders addArimidex or tamoxifen during the off cycle.

During testosterone injections, the natural body testosterone release is inhibited by feedback mechanism through inhibition of pituitary LH. At large doses, even spermatogenesis can be impaired. To allow for the hypothalamic-pituitary axis to recover, it is highly recommended that the drug be tapered off slowly over a period of a few weeks. Sudden discontinuation of the drug can lead to extreme fatigue, weight lossand susceptibility to fractures.

Contraindications

There are some individuals who should avoid testosterone like steroids because it can worsen the clinical condition. These conditions include:

  • those with allergy to the drug
  • males with breast cancer
  • males with prostate cancer
  • Women who are pregnant or breast feeding
  • Individuals who have liver, kidney or heart problems

Side Effects

When Testosterone Cypionate is injected at low doses, the side effects are rare. However, long term use is known to be associated with a varied number of side effects – all of which are reversible when the drug is stopped. For the female who decides to take testosterone, there are virilizing side effects which are not always reversible when the drug is stopped. Like all anabolic steroids, testosterone also has a number of side effects which includes:

  • nausea, vomiting
  • abdominal cramps, diarrhea
  • swelling
  • ncreased /decreased libido
  • headaches
  • acne, oily skin
  • mental change including anger, depression, insomnia
  • diaphoresis
  • loss of hair
  • gynecomastia

When taken by females, the drug definitely can cause virilizing effects like:

  • deepening of voice
  • hoarseness
  • excess hair growth
  • enlarged clitoris
  • irregular menstrual cycles

Testosterone Cypionate is converted into estrogen in the fatty tissues. The estrogen than leads to development of breast enlargement and water retention. This effect is typically seen after the steroid has been used for more than 4 weeks. The gynecomastia does reverse when the steroid is discontinued.

Over dose

Over dose with Testosterone Cypionate is very rare. The drug is usually administered as an injection. If excess dose is injected, there are no acute side effects but the individual may feel sick for a few weeks. Depending on the dose injected, a visit to the hospital or a physician’s office would not be a bad idea.

Dosage

In clinical medicine, Testosterone Cypionate is administered as an injection. The oily suspension is injected only into the muscles.Testosterone Cypionate is available in two strengths 100mg/ml and 200 mg/ml. It is only made for intramuscular injection. The drug can be injected into the buttock area once every 7-12 days. The majority of the Testosterone Cypionate is bound to protein and only 2% is free. The drug is supposed to be injected once a week, but there are some bodybuilders who do inject it every other day.

This is not recommended and can lead to the formation of abscess, sores and skin infections.

The injection site needs to be rotated if the injections are to be continued for a long time. The oily suspension should not be injected into the arms or the abdomen. The dose of Testosterone Cypionate ranges from 50mg-400mg/week, depending on the condition being treated. Bodybuilders tend to inject the higher amount of the drug- 200mg-400mg/week. The drug is then slowly absorbed into the blood stream over the next few days.

Control

Testosterone Cypionate is a controlled substance and classified under class 3 under the Controlled Substance Act. It is only available in the USA with a physician’s prescription. Possession, distribution or sell of this anabolic steroid is considered illegal.

Detection

Anytime an oily suspension of drug is used, the drug does tend to remain in the body for a long time. Testosterone Cypionate and its metabolites can be detected in the urine for as long as 2-3 weeks after the last injection. Because of this long duration in the body, most bodybuilders prefer to take the drug during the off season.

Availability

The majority of bodybuilders get their Testosterone Cypionate from the black market. In the USA the original pharmaceutical product is well controlled and not available for sale. Generic forms of the steroid have been made in Japan, Australia, Mexico, Spain, Brazil and Thailand is all available.

Most bodybuilders use between 200-600mg/week and a vial of 400mg in 2 ml can cost anywhere from $20-$40. this can easily amount to $200 per month depending on the dose.

However, like all things in cyberspace the purity and quality of the product is always in question. And fakes products are plentiful.

30 May

Blood doping is an unlawful method for enhancing athletic execution by falsely boosting the blood’s capacity to convey more oxygen to muscles.

As a rule, blood doping builds the measure of hemoglobin in the circulation system. Hemoglobin is an oxygen-conveying protein in the blood. So expanding hemoglobin permits higher measures of oxygen to reach and fuel a competitor’s muscles. This can enhance stamina and execution, especially in long-separate occasions, for example, running and cycling.

 

Blood doping is banned by the International Olympic Committee and different sports associations.

Sorts of Blood Doping

The three generally utilized sorts of blood doping are:

  • blood transfusions
  • infusions of erythropoietin (EPO)
  • infusions of manufactured oxygen transporters

Here are some more insights about each of these sorts of blood doping:

Blood transfusions. In ordinary medicinal practice, patients may experience blood transfusions to supplant blood lost because of harm or surgery. Transfusions additionally are given to patients who experience the ill effects of low red platelet numbers brought about by pallor, kidney disappointment, and different conditions or medicines.

Illegal blood transfusions are utilized by competitors to help execution. There are two sorts.

Autologous transfusion. This includes a transfusion of the competitor’s own blood, which is drawn and afterward put away for future utilization.

Homologous transfusion. In this sort of transfusion, competitors utilize the blood of another person with the same blood classification.

EPO infusions. EPO is a hormone created by the kidney. It manages the body’s generation of red blood cells.

In medical practice, EPO injections are given to stimulate the production of red blood cells. For example, a synthetic EPO can be used to treat patients with anemia related to chronic or end-stage kidney disease.

Athletes using EPO do so to encourage their bodies to produce higher than normal amounts of red blood cells to enhance performance.

Synthetic oxygen carriers. These are chemicals that have the ability to carry oxygen. Two examples are:

  • HBOCs (hemoglobin-based oxygen carriers)
  • PFCs (perfluorocarbons)

Synthetic oxygen carriers have a legitimate medical use as emergency therapy. It is used when a patient needs a blood transfusion but:

  • human blood is not available
  • there is a high risk of blood infection
  • there isn’t enough time to find the proper match of blood type

Athletes use synthetic oxygen carriers to achieve the same performance-enhancing effects of other types of blood doping: increased oxygen in the blood that helps fuel muscles.